[Urinary polyamines before and after treatment of malignant tumors]

The concentrations of polyamines (putrescine, spermidine and spermine) were determined in urine of twelve patients with malignant tumors before and after therapy and in twelve healthy patients. The results showed significant increase of urinary concentrations of putrescine, spermidine and spermine in urine of 12 malignant tumour patients. The concentration of urinary putrescine was higher approximately by 6.5 times; of spermidine by 5.8 times and of spermine by 9.8 times in comparison with the results in healthy patients. After the therapy the concentration of urinary putrescine was by 42.3% lower; of spermidine by 34.4% and of spermine by 52.2% lower in comparison with the results obtained before the therapy. The possibility of usage of concentration determination of urinary po-therapy efficiency are discussed.