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Auto-erythrocyte sensitisation--the Gardner-Diamond syndrome. A case report
J M Du Toit1, P Jacobs, A R Bird
1University of Cape Town Leukaemia Centre.
Summary
This case study highlights auto-erythrocyte sensitization, a rare cause of easy bruising in Gardner-Diamond syndrome. Diagnosis involved confirming sensitivity to red blood cells, avoiding further costly investigations.
Area of Science:
- Hematology
- Psychodermatology
Background:
- Presents a case of a 34-year-old woman with a 3-year history of unexplained easy bruising.
- Bruising occurred in self-inflicted anatomical sites, yet the patient had no history of abnormal bleeding even after major surgery.
Observation:
- Psychological instability prompted consideration of auto-erythrocyte sensitization.
- The condition was confirmed via subcutaneous injection of autologous red cells and hemolysate.
Findings:
- Subcutaneous injection induced local tenderness and induration, confirming auto-erythrocyte sensitization.
- This specific manifestation of Gardner-Diamond syndrome is unusual.
Implications:
- Highlights an uncommon presentation of Gardner-Diamond syndrome.
- Aims to increase awareness to prevent unnecessary and costly diagnostic investigations for similar cases.