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Updated: Apr 12, 2026

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Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
Published on: January 8, 2013
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Modeling the aging heart: from local respiratory defects to global rhythm disturbances
Konstantin Khrapko1, Natalia Trayanova2, Stanley Nattel3
1Department of Biology, Northeastern University, Boston, MA 02115, USA.
Cell Metabolism
|May 9, 2015
Abstract:
In this issue, Baris et al. (2015) describe cardiac rhythm abnormalities in a mouse model of mitochondrial dysfunction in widely distributed cells of the aging human heart. How do a few metabolically challenged cells disrupt cardiac rhythm? We suggest that these cells provide "crystallization centers" for latent dysfunctional zones to allow arrhythmia emergence.
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