Related Experiment Video
Updated: Apr 12, 2026

Complete and Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Hemorrhagic Shock
Published on: May 19, 2022
Resuming anticoagulation after hemorrhage: A practical approach
Alison Colantino1, Amir K Jaffer2, Daniel J Brotman3
1Hospitalist Program, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Patients on anticoagulant therapy who experience hemorrhage remain at risk for thrombosis. This paper provides a practical framework for individualizing anticoagulation resumption after bleeding events, addressing a gap in evidence-based guidelines.
Area of Science:
- Cardiology
- Hematology
- Clinical Medicine
Background:
- Patients on long-term anticoagulant therapy face a dual risk of recurrent bleeding and thrombosis after a hemorrhage.
- Current clinical practice lacks evidence-based guidelines for managing anticoagulation post-hemorrhage.
Purpose of the Study:
- To offer a practical framework for individualizing the resumption of anticoagulation therapy after a bleeding event.
- To guide physicians in balancing the risks of recurrent bleeding against the need for thrombotic event prevention.
Main Methods:
- This study proposes a clinical decision-making framework.
- The framework considers individual patient factors, bleeding severity, and thrombosis risk.
Main Results:
- A structured approach to anticoagulation management after hemorrhage is presented.
- The framework aims to optimize patient care by tailoring anticoagulation strategies.
Conclusions:
- Individualized assessment is crucial for determining the optimal timing and strategy for resuming anticoagulation after hemorrhage.
- The proposed framework addresses a critical unmet need in managing patients on anticoagulant therapy post-bleeding.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis III: Interprofessional Care
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis IV: Nursing Management
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...

