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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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The Retinoblastoma Gene01:20

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The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Related Experiment Video

Updated: Apr 12, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Familial colorectal cancer.

M S Lung1, A H Trainer1,2,3, I Campbell1

  • 1Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Internal Medicine Journal
|May 9, 2015
PubMed
Summary
This summary is machine-generated.

Identifying genetic predispositions for familial colorectal cancer (CRC) is vital for patient and family management. Understanding gene mutations and clinical features of CRC syndromes aids physicians in diagnosis and care.

Keywords:
adenomatous polyposis colicolorectal neoplasmhereditaryhereditary nonpolyposisneoplastic syndrome

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Area of Science:

  • Oncology
  • Genetics
  • Gastroenterology

Background:

  • Familial colorectal cancer (CRC) necessitates genetic identification for effective management.
  • Physicians need comprehensive knowledge of gene mutations and clinical presentations of hereditary CRC syndromes.

Purpose of the Study:

  • To review the genetics, clinical manifestations, and management of known familial CRC syndromes.
  • To provide a resource for healthcare professionals managing patients with suspected hereditary CRC.

Main Methods:

  • Literature review of established familial colorectal cancer syndromes.
  • Synthesis of information on genetics, clinical features, and management strategies.

Main Results:

  • Summarizes key aspects of Lynch syndrome, familial adenomatous polyposis, MUTYH-associated neoplasia, juvenile polyposis syndrome, and Peutz-Jeghers syndrome.
  • Highlights the importance of understanding specific gene mutations and their associated clinical phenotypes.

Conclusions:

  • Genetic predisposition identification is crucial for familial CRC management.
  • Referral to familial cancer centers for pre-test counseling and follow-up is recommended for individuals with suspected hereditary CRC.