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Related Concept Videos

Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Oral Drug Delivery Systems: Introduction01:23

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Colloidal drug delivery systems: current status and future directions.

Tarun Garg1, Goutam Rath2, Amit Kumar Goyal3

  • 1Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India 09501223252(M); Punjab Technical University, Kapurthala, Punjab, India.

Critical Reviews in Therapeutic Drug Carrier Systems
|May 9, 2015
PubMed
Summary

This paper reviews colloidal drug delivery systems, focusing on vesicular and particulate carriers for therapeutic applications. These systems offer enhanced drug targeting, controlled release, and improved efficacy for various treatments.

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Area of Science:

  • Pharmacology and Pharmaceutics
  • Biomaterials Science
  • Nanotechnology

Background:

  • Colloidal drug delivery systems are crucial for targeted and controlled administration of therapeutics.
  • Vesicular and particulate systems represent key categories within colloidal drug delivery.
  • Existing systems demonstrate significant potential in both research and clinical settings.

Purpose of the Study:

  • To provide a comprehensive overview of colloidal drug delivery systems.
  • To highlight vesicular and particulate systems for drug, biomolecule, and cell delivery.
  • To discuss the advantages and applications of these advanced delivery platforms.

Main Methods:

  • Literature review and synthesis of existing research on colloidal drug delivery.
  • Analysis of commercially available drug delivery systems.
  • Discussion of system characteristics and therapeutic applications.

Main Results:

  • Extensive range of colloidal systems, particularly vesicular and particulate, are detailed.
  • Commercially available systems with research and clinical applications are exemplified.
  • Key advantages include enhanced drug targeting, controlled release, and improved efficacy.

Conclusions:

  • Colloidal drug delivery systems, especially vesicular and particulate types, are vital for modern therapeutics.
  • Their properties facilitate efficient drug, cell, and gene delivery.
  • These systems significantly improve therapeutic outcomes and offer solutions for drug degradation challenges.