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Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Celiac disease.

Peter H R Green1, Benjamin Lebwohl1, Ruby Greywoode1

  • 1Department of Medicine and the Celiac Disease Center, Columbia University Medical Center, New York, NY.

The Journal of Allergy and Clinical Immunology
|May 10, 2015
PubMed
Summary
This summary is machine-generated.

Celiac disease (CD) affects 1% of Western populations and is increasingly recognized globally. Diagnosis and management have advanced with serologic markers, though research continues into environmental factors and non-dietary treatments.

Keywords:
Celiac diseasefood allergygluten intolerance

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Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Celiac disease (CD) is an immune-mediated disorder triggered by gluten in genetically susceptible individuals.
  • Prevalence is approximately 1% in Western countries, with increasing recognition and evidence of underdiagnosis globally.
  • Gluten-related disorders are gaining awareness among healthcare professionals.

Purpose of the Study:

  • To review the pathogenesis, clinical manifestations, diagnosis, and management of celiac disease.
  • To highlight advancements in diagnostic tools and therapeutic strategies.
  • To explore the role of environmental factors and future research directions.

Main Methods:

  • Review of current literature on celiac disease.
  • Analysis of diagnostic advancements, including serologic markers.
  • Examination of therapeutic interventions and ongoing research.

Main Results:

  • Serologic markers have significantly improved CD diagnosis and monitoring.
  • Clinical presentations of CD have evolved over the past decades.
  • A gluten-free diet remains the primary treatment, with novel non-dietary therapies under investigation.

Conclusions:

  • Celiac disease diagnosis and management have been revolutionized by serologic markers.
  • Further research is needed to elucidate environmental factors in CD pathogenesis.
  • Understanding the relationship between CD and other gluten-related disorders is an important future direction.