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Phyllodes tumour with heterologous sarcomatous differentiation: Case series with literature review
Sanjay Warrier1, Sang Y Hwang2, Keagan Gibbings3
1Department of Breast Surgery, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Department of Surgery, Prince of Wales Hospital, Randwick, NSW, Australia; Faculty of Medicine, University of Sydney, Australia; RPA Institute of Academic Surgery, Sydney Local Health District, Australia.
Introduction:
Phyllodes tumours are rare fibroepithelial malignancies of the breast, accounting for less than 1% of malignant breast tumours. Further malignant differentiation of phyllodes tumours can occur, resulting in cases of extremely rare heterologous sarcomatous differentiation.
Presentation Of Case:
Two females in their fifties were diagnosed with malignant phyllodes tumour associated with heterologous sarcomatous differentiation. The first patient, aged 50 had phyllodes tumour with chondrosarcoma, osteosarcoma and ductal carcinoma-in-situ. The second patient, aged 53 had phyllodes tumour with osteosarcoma and liposarcoma.
Discussion:
The association of phyllodes tumour and heterologous sarcomatous differentiation is rare, with only 4 previously reported cases in English literature. The paucity of evidence presents challenges in its management with uncertain prognosis and monitoring requirements for two aforementioned patients.
Conclusion:
Further case series and long-term follow up is required for accurate characterisation of phyllodes tumours with heterologous sarcomatous differentiation.
