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Updated: Apr 12, 2026
High-Resolution 3D Imaging of Rabies Virus Infection in Solvent-Cleared Brain Tissue
Published on: April 30, 2019
Temporal evolution on MRI of successful treatment of rabies
Albert Lu1, Paarth Shah2, Peter Shen1
1Department of Radiology, University of California Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA.
Abstract:
Rabies is a nearly uniformly fatal disease for individuals who develop clinical symptoms. We report a case of a patient with paralytic rabies who survived after being treated with what is now known as Milwaukee protocol. This is only the third known case of rabies survival after being treated with the protocol. We present sequential magnetic resonance imaging (MRI) findings of the brain and lumbar spine throughout the course of her treatment. In doing so, we provide insight into the temporal evolution of MRI findings in the brain and lumbar spine.
Insights
Survival from paralytic rabies is rare. This case demonstrates successful recovery using the Milwaukee protocol, offering new insights into brain and spine imaging during rabies treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Rabies is a viral disease with a near-fatal outcome once clinical symptoms manifest.
- Paralytic rabies presents a significant diagnostic and therapeutic challenge.
- Few documented cases of rabies survival exist.
