Related Experiment Video
Updated: Apr 12, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Panniculitis of the thigh and lung emphysema in a 54-year-old patient]
M Eckhard1, K P Kröll, T Karrasch
1Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen, Justus-Liebig-Universität Gießen, Klinikstr. 33, 35392, Gießen, Deutschland.
Abstract:
This article reports a case of febrile, symmetrical and painful soft tissue swelling on both thighs in a 54-year-old otherwise healthy male patient. Histologically, necrotizing panniculitis of subcutaneous adipose tissue was described as a marker manifestation of a previously unknown alpha-1-antitrypsin (A1AT) deficiency with pulmonary emphysema and low plasma A1AT levels. The PiZZ homozygous form of A1AT could be diagnosed by gene sequencing. Complete remission of panniculitis could be achieved by A1AT replacement therapy.
Related Concept Videos
Pneumonia II: Pathophysiology
Pneumonia III: Complications and Assessment
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Atypical Pneumonia

