Hormonal regulation on bioactive aortic substance (BAS) production
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Updated: Oct 8, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
E Bermejo1, N Maugeri, M Chaud
1Department of Hemostasis and Thrombosis, Instituto de Investigaciones Hematologicas Mariano R. Castex, Buenos Aires, Argentina.
Abstract:
Rat's vessel wall releases a protein named BAS (Bioactive Aortic Substance) whose antiaggregating effect on platelets and inotropy vascular properties have been already described. In this work we have investigated the effects of pregnancy, gonadectomy and gonadectomy with hormonal treatment on the BAS production from rat aortic rings. BAS production in pregnancy and ovariectomized rats was markedly decreased compared to normal rats. Return to normal values was obtained after estradiol treatment in ovariectomized rats. Castration resulted in an increased of BAS production which was suppressed by testosterone treatment.
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