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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Oxidative stress in chronic kidney disease
Atieh Modaresi, Mohsen Nafar, Zahra Sahraei1
1Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. z.sahraei@sbmu.ac.ir.
Iranian Journal of Kidney Diseases
|May 10, 2015
Summary
Chronic kidney disease (CKD) patients experience increased cardiovascular disease and malignancy due to oxidative stress. Antioxidant therapies show promise for managing these complications and improving patient survival.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Patients with chronic kidney disease (CKD) exhibit elevated risks for cardiovascular disease and malignancy.
- CKD pathogenesis involves impaired renal energy, uremia, and an imbalance in antioxidant defenses, leading to increased oxidative stress.
- Common comorbidities in CKD, such as diabetes mellitus, dyslipidemia, and hypertension, exacerbate oxidative stress and inflammation.
Purpose of the Study:
- To provide a comprehensive overview of oxidative stress in CKD.
- To discuss the clinical manifestations and biomarkers associated with oxidative stress in CKD patients.
- To explore the potential of antioxidant therapies as a therapeutic strategy for CKD.
Main Methods:
- Literature review of studies on oxidative stress mechanisms in CKD.
- Analysis of clinical biomarkers for assessing oxidative stress and antioxidant status.
- Evaluation of existing research on antioxidant therapies in CKD patients.
Main Results:
- Oxidative stress is a significant factor contributing to cardiovascular disease and malignancy in CKD.
- Biomarkers for oxidative stress and antioxidant status are available for clinical use in CKD.
- Antioxidant interventions may mitigate uremic cardiovascular toxicity and improve survival rates.
Conclusions:
- Oxidative stress plays a critical role in the progression of CKD and its associated complications.
- Targeting oxidative stress with antioxidant therapies represents a promising therapeutic avenue for CKD management.
- Further research into antioxidant therapies could lead to improved outcomes for CKD patients.
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