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Taste masked thin films printed by jet dispensing
Nikolaos Scoutaris1, Martin Snowden1, Dennis Douroumis1
1Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
International Journal of Pharmaceutics
|May 11, 2015
Summary
Jet dispensing technology effectively masks bitter taste in medications by printing thin films. This method shows excellent taste masking for drug loadings between 20-40% in pharmaceutical applications.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Taste masking bitter drugs is crucial for patient compliance, particularly in pediatric and geriatric populations.
- Developing effective and scalable taste masking technologies remains a significant challenge in pharmaceutical formulation.
Purpose of the Study:
- To introduce and evaluate jet dispensing as a novel taste masking technology for bitter active pharmaceutical ingredients.
- To assess the efficacy of jet-dispensed mucosal films in masking the taste of model bitter drugs.
Main Methods:
- Utilized jet dispensing to print aqueous drug/polymer solutions containing model bitter substances (Cetirizine HCl, Diphenylhydramine HCl, Ibuprofen).
- Embedded drugs within a polymer matrix during the high-speed printing process.
- Performed in vivo evaluation of the jet-dispensed mucosal films for taste masking efficacy.
Main Results:
- Jet dispensing successfully created uniform, accurate, and reproducible thin films with excellent content uniformity.
- In vivo studies demonstrated excellent taste masking for drug loadings ranging from 20% to 40%.
Conclusions:
- Jet dispensing is a viable and effective technology for taste masking bitter drugs in pharmaceutical formulations.
- The method offers advantages in terms of precision, reproducibility, and scalability for producing taste-masked oral films.
