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Updated: Apr 12, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Xanthomatous hypophysitis.

Bishoy Hanna¹, Yan M Li², Timothy Beutler²

¹Department of Surgery, Staten Island University Hospital, 28 Arvin Road, Old Bridge, NJ 08857, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|May 11, 2015

Summary

This summary is machine-generated.

Xanthomatous hypophysitis (XH) is a rare inflammatory pituitary disorder. This case highlights its challenging diagnosis and the effectiveness of radiation therapy for vision improvement.

Keywords:

Pituitary inflammation Primary hypophysitis Xanthomatous hypophysitis

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Area of Science:

Endocrinology
Neurology
Ophthalmology

Background:

Pituitary masses can present with diverse symptoms, including headaches and visual disturbances.
Lymphocytic hypophysitis is an autoimmune inflammatory condition affecting the pituitary gland.

Observation:

A 69-year-old woman initially diagnosed with lymphocytic hypophysitis experienced worsening headaches and vision loss.
Recurrent pituitary mass growth despite initial steroid treatment indicated a need for further investigation.

Findings:

Histopathological re-evaluation revealed xanthomatous hypophysitis (XH), characterized by lipid-laden histiocytes.
Endoscopic transsphenoidal resection and subsequent radiation therapy led to improved vision and lesion stabilization.

Implications:

This case underscores the importance of considering alternative diagnoses in pituitary masses initially presumed to be lymphocytic hypophysitis.
Xanthomatous hypophysitis, though rare, requires a multidisciplinary approach involving neurosurgery, endocrinology, and radiation oncology for optimal management.