Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

4.0K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
4.0K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

564
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
564
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.6K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.6K
Drug Dependence01:17

Drug Dependence

2.0K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Relationship Between Childhood Sexual Abuse and Executive Function for Those in Recovery from Opioid Use Disorder: A Brief Report of a Pilot Study.

Journal of family violence·2026
Same author

Weight Suppression, Brain Reward Response to Food Cues, and Bulimic Behaviours: A Pilot fMRI Study.

European eating disorders review : the journal of the Eating Disorders Association·2026
Same author

Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder.

Nature communications·2026
Same author

Emerging neuromodulation treatments for opioid and stimulant use disorders.

Frontiers in human neuroscience·2025
Same author

Brain network segregation is associated with drug use severity in individuals with opioid use disorder.

Drug and alcohol dependence·2025
Same author

Brain Network Segregation is Associated with Drug Use Severity in Individuals with Opioid Use Disorder.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 12, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.2K

A hyper-connected but less efficient small-world network in the substance-dependent brain.

Ze Wang1, Jesse Suh2, Zhengjun Li3

  • 1Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, China; Center for Cognition and Brain Disorders, Hangzhou Normal University, China; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.

Drug and Alcohol Dependence
|May 11, 2015
PubMed
Summary

Addiction alters the brain's functional connectome (FCM), showing stronger connectivity but reduced communication efficiency. This may drive drug-seeking behaviors by impairing inhibitory control.

Keywords:
Drug addictionFunctional connectomeResting state fMRI

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.7K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.8K

Related Experiment Videos

Last Updated: Apr 12, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.2K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.7K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.8K

Area of Science:

  • Neuroscience
  • Addiction Research
  • Brain Imaging

Background:

  • Prior addiction research focused on limited brain regions, hindering understanding of the whole brain's functional connectome (FCM).
  • Recent advancements allow comprehensive analysis of brain-wide functional interactions.

Purpose of the Study:

  • To characterize functional connectome alterations in cocaine dependence using resting-state functional MRI (rsfMRI).
  • To investigate the relationship between these FCM changes and addiction-related symptoms.

Main Methods:

  • rsfMRI data collected from 20 individuals with cocaine dependence (DRUG) and 19 healthy controls (CTL).
  • Functional connectome (FCM) analysis employed graph theoretical approaches across 90 brain subdivisions.

Main Results:

  • Drug users (DRUG) exhibited stronger functional connectivity compared to controls (CTL).
  • After controlling for network density, DRUG participants showed reduced communication efficiency and small-worldness.

Conclusions:

  • Elevated connectivity in drug users may facilitate rapid, goal-directed drug-seeking behaviors.
  • Diminished communication efficiency and small-worldness suggest impaired inter-regional communication, hindering the inhibition of drug-seeking behaviors.