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A peptide-based fluorescent chemosensor for multianalyte detection.

Peng Wang1, Lixuan Liu1, Panpan Zhou1

  • 1Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.

Biosensors & Bioelectronics
|May 11, 2015
PubMed
Summary
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Researchers developed a novel peptide fluorescent chemosensor (DP-3) for detecting multiple analytes, including zinc, copper, and sulfide ions, in aqueous solutions and cells.

Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Materials Science

Background:

  • Peptide fluorescent chemosensors offer potential for sensitive and selective analyte detection.
  • Developing multifunctional probes for simultaneous detection of various ions remains a challenge.
  • Existing chemosensors often lack stability or efficient intracellular detection capabilities.

Purpose of the Study:

  • To design and synthesize a novel multifunctional peptide fluorescent chemosensor (DP-3).
  • To evaluate DP-3's capability for detecting Zn(2+), Cu(2+), and S(2-) in aqueous solutions and intracellular environments.
  • To investigate the potential of DP-3 as a stable and selective probe for multianalyte sensing.

Main Methods:

  • Solid-phase synthesis of the DP-3 peptide chemosensor.
Keywords:
BiosensingCell imagingFluorescent chemosensorMultianalyte detectionPeptide

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  • Spectroscopic analysis (fluorescence) for ion detection.
  • Cellular uptake and toxicity studies for intracellular biosensing.
  • Determination of detection limits and selectivity for target analytes.

    • Main Results:

    • DP-3 was successfully synthesized with a lysine backbone, histidine, and dansyl groups.
    • DP-3 demonstrated effective detection of Zn(2+), Cu(2+), and S(2-) in aqueous solutions via distinct mechanisms.
    • High selectivity and sensitivity were achieved, with detection limits of 82 nM for Zn(2+) and 78 nM for Cu(2+).
    • Successful intracellular biosensing was actualized with excellent cell permeation and low biotoxicity.

    Conclusions:

    • DP-3 serves as a promising multifunctional peptide fluorescent chemosensor for detecting both cations and anions.
    • The peptide beacon structure enhances stability and enables multianalyte detection, particularly for sulfide ions.
    • This study opens new avenues for developing versatile peptide-based fluorescent chemosensors for environmental and biological applications.