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The Confidence Information Ontology: a step towards a standard for asserting confidence in annotations
Frederic B Bastian1, Marcus C Chibucos2, Pascale Gaudet2
1Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland, Department of Microbiology and Immunology and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD, USA, SIB Swiss Institute of Bioinformatics, 1 Rue Michel Servet, 1211 Geneva, Switzerland, Department of Medicine and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD, USA, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA, School of Information, University of South Florida, Tampa, FL, 33647, USA, Genomics Division, Lawrence Berkeley National Lab, 1 Cyclotron Rd., Berkeley, 94720 CA USA, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland, ETH Zurich, Department of Computer Science, Universitätstr. 19, 8092 Zürich, Switzerland, SIB Swiss Institute of Bioinformatics, Universitätstr. 6, 8092 Zürich, Switzerland and University College London, Gower St, London WC1E 6BT, UK Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland, Department of Microbiology and Immunology and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD, USA, SIB Swiss Institute of Bioinformatics, 1 Rue Michel Servet, 1211 Geneva, Switzerland, Department of Medicine and Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore MD, USA, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA, School of Information, University of South Florida, Tampa, FL, 33647, USA, Genomics Division, Lawrence Berkeley Nat
Biocuration requires standardized confidence assessment for biological annotations. A new Confidence Information Ontology (CIO) aims to improve data reliability and knowledge sharing across resources.
Area of Science:
- Bioinformatics
- Biocuration
- Ontology Development
Background:
- The volume of biological annotations has surged, necessitating methods to evaluate their reliability.
- Current annotation confidence information lacks standardization, hindering knowledge propagation and high-throughput analysis credibility.
Purpose of the Study:
- To identify essential elements for assessing confidence in biological annotations.
- To propose a standardized approach for representing annotation confidence information.
Main Methods:
- Formation of a working group following the Biocuration 2012 conference.
- Development of the Confidence Information Ontology (CIO) to address standardization needs.
Main Results:
- Identification of key components required for evaluating annotation confidence.
- Drafting of the Confidence Information Ontology (CIO) as a foundational tool.
Conclusions:
- A standardized method for annotation confidence is crucial for biocuration.
- The CIO offers a framework for discussing and implementing confidence information standards.
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