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Related Experiment Videos

Tuberculosis presenting as corticosteroid responsive wheezing in infancy.

I C Kitai1, D M Sanders, J Manungo

  • 1Department of Paediatrics, University of Zimbabwe Medical School, Harare.

Tropical and Geographical Medicine
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

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Persistent wheezing in infants may mask serious conditions like tuberculosis. Steroid treatment can temporarily improve symptoms but may worsen the underlying disease if not properly diagnosed.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pulmonology

Background:

  • Persistent wheezing in infants often leads to a diagnosis of reactive airways disease.
  • Corticosteroids, such as prednisolone, are commonly used to manage infant wheezing.
  • The use of corticosteroids can sometimes mask underlying infections.

Observation:

  • A nine-month-old infant with persistent wheezing was treated with oral prednisolone for six months.
  • The child initially showed improvement in symptoms with steroid therapy.
  • At 15 months, disseminated pulmonary tuberculosis was diagnosed via chest X-ray and tracheal aspirate culture.

Findings:

  • Withdrawal of steroids led to a significant worsening of the infant's wheeze and respiratory distress.
  • Antituberculous therapy showed a slow response.

Related Experiment Videos

  • Corticosteroids are recognized as adjuncts in managing bronchial-lymph node tuberculosis.

    • Implications:

    • Wheezing responsive to prednisolone does not automatically indicate hyperreactive airways disease.
    • It is crucial to investigate other potential causes of wheezing, especially in developing countries.
    • Misdiagnosis and delayed treatment of tuberculosis in infants can have severe consequences.