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Metabolomics in cardiovascular diseases
Marta Kordalewska1, Michał J Markuszewski1
1Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland.
Insights
Metabolomics offers insights into cardiovascular diseases (CVDs) by analyzing small molecules. This approach aids in understanding disease mechanisms and developing better diagnostics and treatments for CVDs.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- Effective diagnostics and therapeutics for CVDs require a deeper understanding of their molecular underpinnings.
Purpose of the Study:
- To review the application of metabolomics in understanding cardiovascular disease mechanisms.
- To highlight the utility of untargeted and targeted metabolomic analyses in CVD research.
Main Methods:
- Overview of recent literature on metabolomic studies in various CVDs.
- Focus on diverse analytical platforms and metabolomic strategies.
Main Results:
- Metabolomics provides a snapshot of an organism's physiological state through metabolite analysis.
- Untargeted and targeted metabolomic approaches have been applied to investigate specific CVDs.
Conclusions:
- Metabolomics is a valuable tool for elucidating the molecular pathomechanisms of cardiovascular diseases.
- Further application of metabolomics can contribute to improved CVD diagnostics and therapeutics.
Abstract:
Cardiovascular diseases (CVDs) are the main cause of death globally. There is a need for the development of specific diagnostic methods, more effective therapeutic procedures as well as drugs, which can decrease the risk of deaths in the course of CVDs. For this reason, better understanding and explanation of molecular pathomechanisms of CVDs are essential. Metabolomics is focused on analysis of metabolites, small molecules which reflect the state of an organism in a certain point of time. Application of metabolomics approach in the investigation of molecular processes responsible for CVDs development may provide valuable information. In this article we overviewed recent reports employing application of untargeted and targeted metabolomic analyses in particular CVDs. Moreover, we focused on applications of various analytical platforms and metabolomics approaches which may contribute to the explanation of the pathomechanisms of different cardiovascular diseases.
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