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Metabolomics in cardiovascular diseases
Marta Kordalewska1, Michał J Markuszewski1
1Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland.
Metabolomics offers insights into cardiovascular diseases (CVDs) by analyzing small molecules. This approach aids in understanding disease mechanisms and developing better diagnostics and treatments for CVDs.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiology
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- Effective diagnostics and therapeutics for CVDs require a deeper understanding of their molecular underpinnings.
Purpose of the Study:
- To review the application of metabolomics in understanding cardiovascular disease mechanisms.
- To highlight the utility of untargeted and targeted metabolomic analyses in CVD research.
Main Methods:
- Overview of recent literature on metabolomic studies in various CVDs.
- Focus on diverse analytical platforms and metabolomic strategies.
Main Results:
- Metabolomics provides a snapshot of an organism's physiological state through metabolite analysis.
- Untargeted and targeted metabolomic approaches have been applied to investigate specific CVDs.
Conclusions:
- Metabolomics is a valuable tool for elucidating the molecular pathomechanisms of cardiovascular diseases.
- Further application of metabolomics can contribute to improved CVD diagnostics and therapeutics.
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