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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

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[Human body composition during extended stay in microgravity].

V B Noskov, I A Nichiporuk, G Yu Vasilieva

Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine

|May 12, 2015

Summary

This summary is machine-generated.

Bio-impedancemetry revealed significant body fluid shifts in astronauts during space missions. Extracellular fluid redistributed, and total body fluid, lean mass decreased, while fat mass increased.

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Area of Science:

Space physiology
Biomedical engineering
Human physiology in microgravity

Context:

Bio-impedancemetry is a non-invasive method to assess body composition.
Astronauts experience physiological changes during spaceflight.
The Sprut-2 protocol standardizes physiological measurements.

Purpose:

To analyze body fluid and composition changes in astronauts using bio-impedancemetry.
To quantify the effects of microgravity on body fluid distribution and mass.
To establish a baseline for understanding long-term spaceflight health risks.

Summary:

Bio-impedancemetry was conducted monthly and pre/post-mission on 15 ISS cosmonauts.
Results showed extracellular fluid shifting from legs to the abdomen.
Total body fluid, intracellular, and extracellular fluid volumes decreased; lean body mass reduced, and fat mass increased compared to pre-flight levels.

Impact:

Provides crucial data on astronaut body composition changes during space missions.
Informs strategies for mitigating negative physiological effects of microgravity.
Contributes to the understanding of human adaptation to the space environment.