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Updated: Apr 12, 2026

Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
Published on: June 30, 2016
[Cyclic diadenosine monophosphate--a new second messenger in bacteria--a review]
Abstract:
Cyclic diadenosine monophosphate (c-di-AMP), a new second messenger found recently in bacteria, regulates various aspects of bacterial physiology, including cell growth, cell wall homeostasis and virulence. In addition to its functions in bacterial physiology, c-di-AMP represents a putative bacterial secondary signaling molecule sensed by eukaryotic host cells and triggers innate immunity. The level of c-di-AMP in bacteria is regulated by the activities of diadenylate cyclase (DAC) and phosphodiesterases (PDE) , the former harbors a DisA_N domain, and the latter a DHH or DHH/DHHA1 domain. This review gives an overview on metabolic pathway, regulatory mechanism, receptor proteins and biological function of c-di-AMP in bacteria, as well as its application and trends of development.
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