[IFITM, a common barrier to many viruses].
Kevin Tartour1, Andrea Cimarelli1
1CIRI (centre international de recherche en infectiologie), 69364 Lyon, France - Inserm U1111, 46, allée d'Italie, 69364 Lyon, France - École normale supérieure de Lyon, 46, allée d'Italie, 69364 Lyon, France - CNRS, UMR5308, 46, allée d'Italie, 69364 Lyon, France - Université de Lyon, Lyon I, UMS3444/US8 BioSciences Gerland, 69364 Lyon, France.
Medecine Sciences : M/S
|May 12, 2015
Summary
Organisms evolved cellular proteins, like interferon-induced transmembrane proteins (IFITM), to combat viral infections. This review details IFITM
Area of Science:
- Molecular biology
- Virology
- Immunology
Context:
- Organisms evolve defense mechanisms against pathogens.
- Cellular proteins play a role in modulating viral replication.
- Interferon-induced transmembrane proteins (IFITM) are key antiviral factors.
Purpose:
- To review the antiviral mechanisms of IFITM proteins.
- To highlight IFITM's broad-spectrum antiviral activity.
- To focus on IFITM's interference with HIV replication.
Summary:
- IFITM proteins are crucial cellular components that restrict viral entry and replication.
- These proteins exhibit potent antiviral activity against a diverse range of viruses.
- Specific mechanisms by which IFITM proteins inhibit viral propagation, including HIV, are discussed.
Impact:
- Enhances understanding of innate antiviral immunity.
- Provides insights into potential therapeutic targets for viral diseases.
- Contributes to the knowledge base on host-pathogen interactions.
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