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Formulation factors affecting acceptability of oral medicines in children

Fang Liu1, Sejal Ranmal2, Hannah K Batchelor3

  • 1Department of Pharmacy, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.

International Journal of Pharmaceutics
|May 12, 2015
PubMed

Insights

Medicines

Area of Science:

  • Pharmaceutical Sciences
  • Paediatric Medicine
  • Drug Formulation

Background:

  • Medicinal product acceptability in children and caregivers is crucial for treatment safety and efficacy.
  • Regulatory bodies require demonstration of paediatric formulation acceptability during product development.
  • Current scientific evidence on age-appropriateness and acceptability of different dosage forms is fragmented.

Purpose of the Study:

  • To highlight formulation factors influencing the acceptability of oral medicines in children.
  • To identify knowledge gaps in paediatric formulation development.
  • To explore the utility of adult study findings for paediatric drug development.

Main Methods:

  • Review of scientific literature on medicine acceptability in children.
  • Analysis of formulation factors impacting oral medicine acceptance.
  • Discussion of findings from adult population studies relevant to paediatrics.

Main Results:

  • Formulation characteristics significantly impact the acceptability of oral medicines for paediatric patients.
  • Specific formulation factors require further investigation for diverse paediatric populations.
  • Adult data can offer preliminary insights for paediatric formulation strategies.

Conclusions:

  • Understanding formulation factors is key to improving paediatric medicine acceptability.
  • Further research is needed to address knowledge gaps in paediatric drug formulation.
  • A strategic approach integrating existing knowledge and new research is essential for effective paediatric formulation development.

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