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Basophil Activation Test for Allergy Diagnosis
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Basophils in inflammation.

Christian Schwartz1, Joerg U Eberle1, David Voehringer1

  • 1Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.

European Journal of Pharmacology
|May 12, 2015
PubMed
Summary
This summary is machine-generated.

Basophils, similar to mast cells, release mediators upon activation. This review covers their dual roles in promoting and suppressing inflammation in skin, lung, and gut allergic responses.

Keywords:
Allergic asthmaAnaphylaxisAtopic dermatitisBasophilsFood allergy

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Basophils and mast cells share functional similarities, including expressing the high-affinity IgE receptor (FcεRI).
  • Both cell types rapidly release mediators upon IgE-mediated activation.
  • Unlike mast cells, basophils mature in bone marrow and have a short lifespan (2-3 days).

Purpose of the Study:

  • To review recent advances in understanding basophil functions.
  • To explore both pro- and anti-inflammatory roles of basophils.
  • To examine basophil involvement in allergic inflammation of the skin, lung, and intestine in murine models and humans.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of studies on murine models of allergic inflammation.
  • Examination of human studies on allergic inflammation.

Main Results:

  • Basophil numbers increase with IL-3 or TSLP.
  • Basophils migrate into tissues to promote type 2 immune responses.
  • Basophils exhibit both pro- and anti-inflammatory functions in allergic conditions.

Conclusions:

  • Basophils play a complex role in allergic inflammation.
  • Understanding basophil functions is crucial for developing new allergy treatments.
  • Further research is needed to fully elucidate the therapeutic potential of targeting basophils.