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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Oxidative stress in benign prostate hyperplasia.

N Zabaiou1, D Mabed2, J M Lobaccaro3

  • 1Laboratory of Molecular Toxicology, Department of Molecular and Cellular Biology, Faculty of Science, University of Jijel, Jijel, Algeria.

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PubMed
Summary

Benign prostate hyperplasia is linked to oxidative stress, with higher malondialdehyde (MDA) and lower glutathione (GSH) levels. Antioxidant enzyme activity also decreased in patients with this common condition.

Keywords:
Antioxidant enzymesMDAbenign prostate hyperplasiaglutathioneoxidative stress

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Area of Science:

  • Urology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Benign prostate hyperplasia (BPH) is a prevalent public health issue in aging men.
  • Oxidative stress is implicated in various chronic diseases, but its role in BPH requires further elucidation.
  • Jijel faces a significant burden from BPH, necessitating local research into its underlying mechanisms.

Purpose of the Study:

  • To investigate the status of oxidative stress in men with benign prostate hyperplasia.
  • To quantify specific biomarkers of oxidative damage and antioxidant defense in prostate tissues.
  • To explore the relationship between oxidative stress markers and the development of BPH.

Main Methods:

  • Prostate tissues were collected from 10 men undergoing transvesical adenomectomy for BPH.
  • Cytosolic levels of malondialdehyde (MDA) and glutathione (GSH) were measured.
  • Activities of key antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase were assessed.

Main Results:

  • Increased cytosolic malondialdehyde (MDA) levels were observed in BPH tissues.
  • Significant depletion of cytosolic glutathione (GSH) concentrations was noted.
  • A marked decrease in the activity of all measured antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase) was found.

Conclusions:

  • The development of benign prostate hyperplasia is associated with an impaired oxidative status.
  • Elevated MDA and depleted GSH, coupled with reduced antioxidant enzyme activity, highlight the role of oxidative stress in BPH pathogenesis.
  • Understanding the contribution of oxidative stress may offer new avenues for BPH management.