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Serial Enrichment of Spermatogonial Stem and Progenitor Cells SSCs in Culture for Derivation of Long-term Adult Mouse SSC Lines
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The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage

Takashi Tanaka1, Mito Kanatsu-Shinohara, Takashi Shinohara

  • 1Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

The Journal of Reproduction and Development
|May 12, 2015
PubMed
Summary

Retinoblastoma 1 (Rb1) is crucial for spermatogonial stem cell (SSC) self-renewal and preventing DNA damage. Its deficiency causes cell cycle arrest and apoptosis, highlighting the CDKN1B-RB1-E2F1 pathway

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