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Published on: October 19, 2016
Plasma soluble vascular adhesion protein-1 concentration correlates with arterial stiffness: A cross-sectional study
Da-Wei Chen1, Rui-Min Zhao2, Ying Jin1
1Geriatric Institute, The General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
Background:
Arterial stiffness is related to inflammation, oxidative stress, advanced glycation end products (AGEs), and endothelial dysfunction. Vascular adhesion protein-1 (VAP-1) is both as an adhesion molecule involving in inflammation and as an amine oxidase producing aldehyde and hydrogen peroxide involved in protein cross-linking, oxidative stress and endothelial injury.
Objective:
We explored the associations of plasma soluble VAP-1 (sVAP-1) with arterial stiffness.
Design:
Cross-sectional study.
Setting:
Health Examination Center at the General Hospital of the Air Force in Beijing, China.
Subjects:
568 Han Chinese healthy persons living in Beijing (aged 50.7 ± 8.0 years).
Methods:
sVAP-1 concentration was assessed by enzyme-linked immunosorbent assay. Arterial stiffness was measured as brachial-ankle pulse wave velocity (baPWV) on both left and right sides of the examinees, and the larger and the mean values were recorded. Cardiovascular risk factors were investigated.
Results:
sVAP-1 was significantly associated with maximal or mean baPWV in subjects of age ≥ 60 years after adjusting for baPWV-related confounders (β=36.922, p<0.05 or β=32.512, p<0.05) or after adjusting for all the variables (β=37.924, p<0.05 or β=33.193, p<0.05), but not in subjects of age <60 years. sVAP-1 had an independent and positive correlation with age (r=0.222, p<0.001).
Conclusions:
Plasma sVAP-1, increased with age, is associated with arterial stiffness in older individuals. VAP-1 may be important mechanism for vascular aging.
