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Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

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Published on: January 15, 2016

Pallidal and caudate volumes correlate with walking function in multiple sclerosis.

Robert W Motl¹, Elizabeth A Hubbard¹, Niranjana Sreekumar²

¹Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, USA.

Journal of the Neurological Sciences

|May 12, 2015

Summary

Subcortical gray matter (SGM) structures, especially the pallidum and caudate, are linked to walking dysfunction in multiple sclerosis (MS). These findings highlight potential targets for improving mobility in MS patients.

Keywords:

Basal ganglia Imaging MRI Multiple sclerosis Thalamus Walking

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Published on: July 24, 2019

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Walking dysfunction is a significant challenge for individuals with multiple sclerosis (MS).
Subcortical gray matter (SGM) structures, including the thalamus and basal ganglia, are implicated in motor control, but their specific role in MS-related gait impairment is not well understood.

Purpose of the Study:

To investigate the relationship between the volumes of specific SGM structures (thalamus, caudate, putamen, pallidum) and walking performance in MS patients.
To identify which SGM structures are most strongly associated with gait abnormalities in MS.

Main Methods:

Sixty-one MS patients underwent brain MRI and completed the 6-minute walk (6MW) and timed 25-foot walk (T25FW) tests.
Volumes of the thalamus, caudate, putamen, pallidum, and whole-brain white and gray matter were quantified from 3D T1-weighted images.
Statistical analyses included bivariate and partial correlations, controlling for relevant covariates, and hierarchical linear regression to determine the strongest SGM correlate.

Main Results:

Bivariate correlations revealed significant associations between 6MW and T25FW performance and the volumes of the thalamus, caudate, pallidum, and putamen.
In partial correlations, significant relationships persisted between walking outcomes and the volumes of the caudate and pallidum.
Hierarchical linear regression identified pallidum volume as the strongest subcortical gray matter correlate of both 6MW and T25FW performance.

Conclusions:

This study provides novel evidence linking specific SGM structures, notably the pallidum and potentially the caudate, to walking performance in MS.
These findings suggest that SGM integrity, particularly in the pallidum, may be a crucial factor influencing gait in multiple sclerosis.