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Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review

Hui-qin Li1, Jing-jing Wei1, Wan Xia1

  • 1Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Acta Pharmacologica Sinica
|May 12, 2015
PubMed

Insights

Promoting blood circulation and removing blood stasis (PBCRBS) therapy may improve neurological deficits and reduce complications in acute intracerebral hemorrhage (ICH) patients. However, more rigorous trials are needed to confirm its efficacy and safety.

Area of Science:

  • Neurology
  • Integrative Medicine
  • Pharmacology

Background:

  • Acute intracerebral hemorrhage (ICH) is a severe neurological condition with high mortality and disability rates.
  • Traditional Chinese Medicine (TCM) therapies, such as promoting blood circulation and removing blood stasis (PBCRBS), are widely used in China for ICH.
  • Evidence on the efficacy and safety of PBCRBS for ICH requires systematic evaluation.

Purpose of the Study:

  • To systematically review and meta-analyze the available evidence on PBCRBS therapy for Chinese patients with acute ICH.
  • To assess the impact of PBCRBS on neurological function, hematoma volume, mortality, and adverse events.
  • To identify commonly used herbal compositions in PBCRBS for ICH.

Main Methods:

  • A systematic search of six databases was conducted up to November 2013.
  • Studies meeting specific quality criteria (assessed in ≥ 4 domains with 'yes' using the Cochrane RoB tool) were included.
  • Meta-analysis was performed to synthesize data on outcomes and herbal components.

Main Results:

  • Nine randomized controlled trials involving 798 patients were included in the meta-analysis.
  • PBCRBS therapy, as monotherapy or adjuvant treatment, demonstrated potential benefits in improving neurological deficits, reducing hematoma and edema volume, and lowering mortality and dependency.
  • Fewer adverse effects were observed compared to conventional Western treatments. Commonly used agents included Xueshuantong Injection, Fufang Danshen Injection, Buyang Huanwu Decoction, Liangxue Tongyu formula, and specific herbs like danshen root, sanqi, and leech.

Conclusions:

  • While preliminary findings suggest potential benefits of PBCRBS for acute ICH, the evidence is limited.
  • High clinical heterogeneity and a small number of included studies necessitate caution.
  • Further large-scale, rigorously designed randomized controlled trials are essential to establish the definitive efficacy and safety of PBCRBS for ICH.
Abstract

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