Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

LRRC8-Mediated Glutamate Release from Astrocytes Is Not Increased During the Initiation of Experimental Temporal Lobe Epilepsy.

International journal of molecular sciences·2026

Same author

AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum.

Glia·2025

Same author

Correction: Induced Overexpression of Connexin43 in Astrocytes Attenuates the Progression of Experimental Temporal Lobe Epilepsy.

Neurochemical research·2025

Same author

Induced Overexpression of Connexin43 in Astrocytes Attenuates the Progression of Experimental Temporal Lobe Epilepsy.

Neurochemical research·2025

Same author

Targeting necroptosis protects against astrocyte death and hippocampal sclerosis in experimental temporal lobe epilepsy.

The Journal of physiology·2025

Same author

The Concept of Neuroglia - the State of the Art Circa 1900.

Glia·2025

Same journal

Time as the language of Behavior: events, sequences, patterns and meanings.

Journal of neuroscience methods·2026

Same journal

Detection of cochlear microphonic for differential diagnosis between auditory neuropathy mice and noise-induced sensorineural hearing loss mice.

Journal of neuroscience methods·2026

Same journal

Assessment metrics for pain control in rats: A methodological commentary.

Journal of neuroscience methods·2026

Same journal

Infant EEG preprocessing pipelines: A capability framework and current gaps in practice.

Journal of neuroscience methods·2026

Same journal

Methods for measuring neural activity during voluntary wheel running.

Journal of neuroscience methods·2026

Same journal

Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.

Journal of neuroscience methods·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 12, 2026

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Published on: June 29, 2022

Chemically-induced TLE models: Topical application.

John Jefferys¹, Christian Steinhäuser², Peter Bedner²

¹Department of Pharmacology, University of Oxford, Oxford, UK.

Journal of Neuroscience Methods

|May 12, 2015

Summary

This summary is machine-generated.

Chemically induced animal models are crucial for studying epilepsy mechanisms, particularly temporal lobe epilepsy. This review compares models, evaluating their reliability and similarity to human epilepsy conditions.

Keywords:

Astrocyte Epileptogenesis Kainate Pilocarpine Temporal lobe epilepsy

More Related Videos

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

Published on: February 27, 2018

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

Published on: August 17, 2021

Related Experiment Videos

Last Updated: Apr 12, 2026

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala

Published on: June 29, 2022

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

Published on: February 27, 2018

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

Published on: August 17, 2021

Area of Science:

Neuroscience
Epilepsy Research
Animal Modeling

Background:

Epilepsy is a complex neurological disorder with diverse clinical presentations.
Understanding epileptogenesis is limited by human clinical studies and resected tissue analysis.
Animal models are essential for investigating epilepsy mechanisms.

Purpose of the Study:

To review and compare chemically induced animal models of epilepsy.
To focus on models that mimic human temporal lobe epilepsies.
To discuss the advantages and disadvantages of different topical application agents.

Main Methods:

Review of chemically induced animal models for epilepsy.
Comparison of models based on topical application of agents.
Evaluation of parameters: reliability, mortality, functional and morphological alterations.

Main Results:

Chemically induced models offer valuable insights into epileptogenesis.
Different models recapitulate specific aspects of human temporal lobe epilepsy.
Comparison highlights variations in reliability, mortality, and human-like alterations across models.

Conclusions:

Chemically induced animal models are indispensable for studying epilepsy.
Model selection requires careful consideration of reliability and human condition similarity.
Further research can refine these models for better understanding of epileptogenesis.