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Anti-inflammatory and immunoregulatory functions of artemisinin and its derivatives
Chenchen Shi1, Haipeng Li2, Yifu Yang1
1Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abstract:
Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.
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