Related Experiment Video

Updated: Apr 12, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

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Antifibrotic activity of acylated and unacylated ghrelin

Elia Angelino1, Simone Reano1, Michele Ferrara1

  • 1Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.

International Journal of Endocrinology
|May 12, 2015
PubMed

Insights

Ghrelin peptides, both acylated and unacylated, show promise in combating fibrosis. These compounds possess anti-inflammatory and anti-apoptotic properties beneficial for treating fibrotic diseases.

Area of Science:

  • Biomedical Sciences
  • Molecular Biology
  • Pathology

Background:

  • Fibrosis is a significant health concern, often marking the end stage of chronic diseases.
  • Tissue injury initiates inflammation, leading to fibroblast activation and excessive extracellular matrix deposition.
  • Ghrelin, a peptide hormone, exists in acylated and unacylated forms with distinct and overlapping biological functions.

Purpose of the Study:

  • To review the therapeutic potential of ghrelin peptides in fibrotic conditions.
  • To consolidate evidence on the anti-fibrotic effects of acylated and unacylated ghrelin.
  • To explore ghrelin's role in mitigating fibrosis across various pathologies and experimental models.

Main Methods:

  • Literature review of studies investigating ghrelin peptides and fibrosis.
  • Analysis of experimental models exhibiting fibrotic characteristics.
  • Examination of diverse pathological conditions associated with fibrosis.

Main Results:

  • Ghrelin peptides demonstrate anti-inflammatory, antioxidative, and antiapoptotic activities.
  • Evidence suggests ghrelin's potential to prevent or reduce pathological fibrosis.
  • Both acylated and unacylated ghrelin show biological activities relevant to fibrotic disease management.

Conclusions:

  • Ghrelin peptides represent a promising therapeutic strategy for fibrotic diseases.
  • Further research into ghrelin's anti-fibrotic mechanisms is warranted.
  • Targeting ghrelin pathways could offer novel treatments for conditions characterized by fibrosis.

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