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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Chromatin Modification in iPS Cells01:32

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Related Experiment Video

Updated: Apr 12, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Epigenetherapy, a new concept.

Tiia Husso, Mikko P Turunen, Nigel Parker

    Biomolecular Concepts
    |May 12, 2015
    PubMed
    Summary

    Small RNAs regulate gene expression epigenetically. Epigenetherapy uses small RNAs for therapeutic gene regulation, offering potential for research and clinical applications.

    Area of Science:

    • Molecular Biology
    • Epigenetics
    • Gene Therapy

    Background:

    • Small RNAs are known to regulate gene transcription via promoter interactions and histone modification.
    • The precise mechanisms of small RNA function are still under investigation.
    • The ability to modulate endogenous gene expression using small RNA molecules has been validated experimentally.

    Purpose of the Study:

    • To explore the potential of epigenetherapy, a novel approach utilizing small RNAs for gene regulation.
    • To highlight the feasibility of using small RNAs to control gene expression through epigenetic mechanisms.
    • To discuss the broad applicability of small RNA-based therapies in research and clinical settings.

    Main Methods:

    • Investigating the interaction of small RNAs with promoter regions.

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  • Analyzing the modification of the histone code by small RNAs.
  • Demonstrating the activation or repression of endogenous gene expression in vitro and in vivo.

    • Main Results:

    • Small RNAs can epigenetically regulate gene transcription.
    • The delivery of small RNAs to cells can modulate gene expression.
    • Experimental evidence supports the in vitro and in vivo feasibility of small RNA-mediated gene regulation.

    Conclusions:

    • Epigenetherapy offers a promising strategy for therapeutic gene regulation by leveraging small RNAs.
    • This approach holds significant potential for both fundamental scientific research and clinical translation.
    • Small RNA-based epigenetherapy could revolutionize the treatment of diseases by targeting gene expression epigenetically.