Cytochemical detection of nickel in endometrial carcinoma during progestogen treatment

During progestogen treatment, nickel ions were detected in the human endometrial tissue of patients with endometrial carcinoma by the dimethyloxime cytochemical method. In this paper, the mechanism of action of nickel is dealt with and, because nickel ions have earlier not be detected in human endometrial carcinomatous tissues, the question arises as a result of what kind of cell biological processes, nickel ions appear in the cells of endometrial carcinoma. It is still to be answered whether the progestogen treatment applied can be correlated with the appearance of the trace element in the carcinomatous cell.