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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

955
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
955
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.1K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.1K
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

1.3K
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.3K
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

523
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
523
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

2.0K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.0K
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

465
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
465

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Related Experiment Video

Updated: Apr 12, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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[Interstitial nephritis in rheumatic diseases].

P Korsten1, G A Müller

  • 1Klinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Deutschland.

Zeitschrift Fur Rheumatologie
|May 13, 2015
PubMed
Summary

Interstitial nephritis, a kidney disorder, is linked to rheumatic diseases. Early diagnosis and treatment with immunosuppressants are key for managing this condition.

Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Context:

  • Interstitial nephritis accounts for 12% of end-stage renal disease in Germany.
  • It's an inflammatory kidney disorder affecting the interstitium and tubules.
  • Drug-induced causes (antibiotics, NSAIDs, PPIs) are most common.

Purpose:

  • To review clinical and laboratory findings of interstitial nephritis in rheumatic diseases.
  • To highlight specific rheumatic conditions associated with interstitial nephritis.
  • To outline current therapeutic strategies.

Summary:

  • Rheumatic diseases frequently impact kidneys, causing interstitial nephritis.
  • Conditions like sarcoidosis, TINU syndrome, Sjogren's syndrome, and IgG4-related disease often present with interstitial nephritis.

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  • Lupus, scleroderma, DRESS syndrome, and granulomatosis with polyangiitis are less commonly associated.

    • Impact:

    • Provides a comprehensive overview for clinicians managing kidney involvement in rheumatic diseases.
    • Emphasizes the importance of recognizing interstitial nephritis in the context of rheumatological conditions.
    • Informs treatment decisions, with glucocorticoids as first-line therapy and other immunosuppressants for refractory cases.