Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

848
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
848
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

801
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
801
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

767
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
767
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

884
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
884
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

695
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
695
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ambulatory norepinephrine infusion in severe idiopathic orthostatic hypotension (Bradbury Eggleston syndrome)

Cardiovascular drugs and therapy·1999
Same author

Does remodeling occur in the diseased human saphenous vein bypass grafts? An intravascular ultrasound study.

International journal of cardiac imaging·1999
Same author

Fusion of angiography and intravascular ultrasound in vivo: establishing the absolute 3-D frame orientation.

IEEE transactions on bio-medical engineering·1999
Same author

M-mode analysis of mitral annulus motion for detection of pseudonormalization of the mitral inflow pattern.

The American journal of cardiology·1999
Same author

Comparison of normal and diseased pulmonary artery morphology by intravascular ultrasound and histological examination.

International journal of cardiac imaging·1999
Same author

Early clinical experience with the implantation of a novel synthetic coronary stent graft.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·1999
Same journal

[Advancing cardiovascular prevention : Evidence-based design of healthy and sustainable food environments].

Herz·2026
Same journal

[Effects of air pollution on cardiovascular health].

Herz·2026
Same journal

[Heart and climate].

Herz·2026
Same journal

Multidimensional psychosocial screening in routine cardiac care: preliminary findings from a cross-sectional survey.

Herz·2026
Same journal

[Noise and the heart].

Herz·2026
Same journal

[The cardiovascular exposome: areas of action for prevention and practical cardiology].

Herz·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K

[Noncompaction cardiomyopathy].

J Shariati1, T Schlosser, R Erbel

  • 1Westdeutsches Herz- und Gefäßzentrum, Klinik für Kardiologie, Universitätsklinikum Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Dautschland, jawid.shariati@uk-essen.de.

Herz
|May 13, 2015
PubMed
Summary
This summary is machine-generated.

Noncompaction cardiomyopathy (NCCM) is a genetic heart muscle disease affecting ventricle walls. Early diagnosis via imaging and symptom analysis is crucial to prevent heart failure and sudden cardiac death.

More Related Videos

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.6K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.9K

Related Experiment Videos

Last Updated: Apr 12, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.6K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.9K

Area of Science:

  • Cardiology
  • Genetics
  • Pathology

Context:

  • Noncompaction cardiomyopathy (NCCM) is a rare genetic myocardial disorder.
  • Characterized by a unique two-layered ventricle wall structure with a noncompacted inner layer and prominent trabeculations.
  • Historically described with congenital cardiac disorders, NCCM can also present as isolated left ventricle cardiomyopathy (ILVCN).

Purpose:

  • To define the morphological characteristics of noncompaction cardiomyopathy.
  • To highlight the diagnostic challenges and potential complications of NCCM.
  • To emphasize the importance of multimodal investigation for accurate diagnosis.

Summary:

  • NCCM involves a thickened, bilayered ventricular wall with a spongy inner layer and deep recesses.
  • While typically affecting the left ventricle, right ventricular involvement is increasingly recognized.
  • Delayed diagnosis can lead to severe outcomes including heart failure, arrhythmias, and sudden cardiac death.

Impact:

  • NCCM diagnosis requires a multimodal approach, including echocardiography and cardiac MRI (CMR).
  • Prompt diagnosis and management are essential to mitigate risks of heart failure, malignant arrhythmias, and embolic events.
  • Understanding NCCM's genetic basis and clinical presentation aids in improved patient outcomes and therapeutic strategies.