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Updated: Apr 12, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Brain MR diffusion tensor imaging in Kennedy's disease.

Francesco Garaci¹, Nicola Toschi², Simona Lanzafame³

¹Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, University Hospital Tor Vergata, Italy Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Italy.

The Neuroradiology Journal

|May 13, 2015

Summary

This summary is machine-generated.

Diffusion-tensor imaging revealed white matter changes in Kennedy's disease patients. These microstructural alterations correlate with disease severity and duration, suggesting multisystem involvement.

Keywords:

ALSFRS DTI Kennedy’s disease TBSS disease duration fractional anisotropy mean diffusivity

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Area of Science:

Neuroimaging
Neurology
Biomedical Engineering

Background:

Kennedy's disease (KD) is a progressive motor neuron disorder.
Investigated white matter microstructure in KD patients using diffusion-tensor imaging (DTI).
Assessed disease severity with the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS).

Observation:

DTI metrics including fractional anisotropy (FA) and diffusivities (MD, L1, L2, L3) were analyzed.
Tract-based spatial statistics (TBSS) correlated DTI measures with ALSFRS and disease duration (DD).

Findings:

Low ALSFRS correlated with reduced FA and increased L3 in specific white matter tracts.
Longer disease duration associated with reduced FA and increased L1 in various white matter regions.

Implications:

Findings suggest white matter microstructural changes in KD.
Correlations support multisystem involvement in KD pathogenesis.
These changes may contribute to clinical disability in patients.