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Sports in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy and desmosomal mutations

A C Sawant1, H Calkins

  • 1Department of Medicine, Division of Cardiology, The Johns Hopkins Hospital, 1800 Orleans Street/Zayed Tower 7125R, 21287, Baltimore, Maryland, USA.

Herz
|May 13, 2015
PubMed

Insights

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) patients face risks from exercise. Current evidence suggests limiting physical activity to mitigate adverse outcomes and sudden cardiac death risk.

Area of Science:

  • Cardiology
  • Genetics
  • Sports Medicine

Background:

  • Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a rare genetic heart condition.
  • It leads to life-threatening arrhythmias and sudden cardiac death.
  • Environmental factors, including exercise, are increasingly implicated in ARVD/C.

Purpose of the Study:

  • To review the current evidence on the impact of exercise in ARVD/C patients.
  • To inform recommendations regarding physical activity for individuals with ARVD/C.

Main Methods:

  • Literature review of recent studies on ARVD/C and exercise.
  • Analysis of evidence linking exercise to disease progression and adverse events.

Main Results:

  • Exercise may be associated with adverse outcomes in ARVD/C patients.
  • Some research suggests an acquired form of ARVD/C induced by exercise.
  • Recommendations favor exercise limitation for all ARVD/C patients.

Conclusions:

  • Patients diagnosed with ARVD/C should limit exercise.
  • This recommendation applies regardless of genetic mutation status.
  • Further research may clarify the role of exercise in acquired ARVD/C.

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