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Association of Mitral Valve Prolapse With Infective Endocarditis Due to Viridans Group Streptococci

Daniel C DeSimone1, Christopher V DeSimone2, Imad M Tleyjeh3

  • 1Division of Infectious Diseases.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|May 13, 2015
PubMed

Insights

Mitral valve prolapse is strongly linked to viridans group streptococcal infective endocarditis (IE). This finding clarifies specific pathogen associations in patients with cardiac valve abnormalities, improving risk assessment for IE.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Certain cardiac valve abnormalities increase infective endocarditis (IE) risk.
  • Specific pathogen associations with these abnormalities are not well-established.

Purpose of the Study:

  • To investigate the association between specific cardiac valve abnormalities and pathogens in infective endocarditis cases.
  • To identify if mitral valve prolapse is linked to particular IE-causing bacteria.

Main Methods:

  • Population-based cohort study.
  • Analysis of cases from Olmsted County, Minnesota.

Main Results:

  • A strong association was found between mitral valve prolapse and viridans group streptococcal IE.
  • This suggests a specific pathogen link for this common valve abnormality.

Conclusions:

  • Mitral valve prolapse is significantly associated with viridans group streptococcal infective endocarditis.
  • Understanding these associations can refine diagnostic and preventative strategies for IE in at-risk populations.
Keywords:
endocarditisvalvulopathyviridans group streptococci

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