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Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

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Published on: July 17, 2021

Microchip-based forensic short tandem repeat genotyping.

Yong Tae Kim¹, Hyun Young Heo¹, Shin Hye Oh²

¹Department of Chemical and Biomolecular Engineering (BK21 plus program), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

Electrophoresis

|May 13, 2015

Summary

Micro total analysis systems (μTAS) enable rapid, portable genetic analysis. This review highlights advancements in lab-on-a-chip (LOC) technology for on-site short tandem repeat (STR) typing, crucial for human identification.

Keywords:

Forensics Integration Lab-on-a-chip Micro-total analysis system Short tandem repeat

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Area of Science:

Forensic Science
Biotechnology
Analytical Chemistry

Background:

Micro total analysis systems (μTAS) and lab-on-a-chip (LOC) offer advantages like low sample consumption and portability.
Genetic applications, particularly short tandem repeat (STR) typing, are increasingly explored on these platforms.
STR typing is vital for human identification in forensics, disaster victim identification, and paternity testing.

Purpose of the Study:

To review recent progress in microtechnology for integrated short tandem repeat (STR) typing.
To highlight key advancements in μTAS/LOC for on-site genetic analysis.

Main Methods:

Review of fluorescence labeling techniques.
Microchip-based DNA purification methods.
On-chip polymerase chain reaction (PCR) amplification.
Capillary electrophoretic microdevices.
Fully integrated microdevices for STR typing.

Main Results:

Microtechnology demonstrates potential to replace conventional analytical tools for STR typing.
Total integration of STR processes on a single chip for on-site analysis is achievable.
Representative results for key STR typing components on-chip are presented.

Conclusions:

μTAS/LOC technology is advancing towards fully integrated, on-site STR typing solutions.
These advancements hold significant promise for forensic applications and human identification.
The review showcases the potential of microfluidic devices for rapid and efficient genetic analysis.