Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

617
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
617
Structural Protein Function01:56

Structural Protein Function

3.4K
3.4K
Structural Protein Function01:56

Structural Protein Function

30.6K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.6K
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

3.1K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
3.1K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

15.0K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
15.0K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

4.8K
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the Antibacterial and Antibiofilm Efficacy of <i>Psammogeton biternatum</i> Edgew and Identification of a Novel Quinoline Alkaloid using X-ray Crystallography.

ACS omega·2024
Same author

Health risk assessment of lead and cadmium exposure from food and snuff in Pakistani population.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2024
Same author

GmSTOP1-3 regulates flavonoid synthesis to reduce ROS accumulation and enhance aluminum tolerance in soybean.

Journal of hazardous materials·2024
Same author

Antiurolithic activity of Zaleya pentandra (L.) C Jeffrey in ethylene glycol-induced calcium oxalate crystal rat model; A scientific validation of traditional use for kidney stone prevention.

Journal of ethnopharmacology·2024
Same author

Boron toxicity in plants: understanding mechanisms and developing coping strategies; a review.

Plant cell reports·2024
Same author

Exploring mixture estimators in stratified random sampling.

PloS one·2024

Related Experiment Video

Updated: Apr 12, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

3.6K

Prostratin: An Overview.

Ghulam Abbas Miana, Muhammad Riaz1, Syed Shahzad-ul-Hussan

  • 1Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad, (AJK) Pakistan. mriazm1@yahoo.com.

Mini Reviews in Medicinal Chemistry
|May 13, 2015
PubMed
Summary
This summary is machine-generated.

Prostratin, a terpenoid, shows therapeutic potential by inhibiting HIV-1 and exhibiting tumor-suppressing activity. It works by activating protein kinase C (PKC) pathways, offering a unique safety profile compared to other phorbol esters.

More Related Videos

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
07:56

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

Published on: January 17, 2012

29.4K
A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

12.4K

Related Experiment Videos

Last Updated: Apr 12, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
10:31

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

Published on: February 3, 2022

3.6K
Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
07:56

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

Published on: January 17, 2012

29.4K
A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

12.4K

Area of Science:

  • Natural Products Chemistry
  • Molecular Pharmacology
  • Drug Discovery

Background:

  • Terpenoids, including prostratin, possess diverse therapeutic properties.
  • Prostratin, a phorbol ester isolated from Pimelea prostrate, has a unique chemical structure.
  • Traditional Samoan medicine utilized prostratin for conditions like jaundice with no significant side effects.

Purpose of the Study:

  • To review the therapeutic potential of prostratin.
  • To elucidate the molecular mechanisms underlying prostratin's biological activities.
  • To highlight prostratin's distinct pharmacological profile compared to other phorbol esters.

Main Methods:

  • Literature review of prostratin's isolation, characterization, and biological activities.
  • Analysis of prostratin's chemical structure and synthesis pathways.
  • Examination of prostratin's role in HIV-1 inhibition and tumor suppression.

Main Results:

  • Prostratin inhibits HIV-1 infection by down-regulating cellular receptors via protein kinase C (PKC) activation, reducing viral latency.
  • Unlike carcinogenic phorbol esters, prostratin demonstrates tumor-suppressing activity.
  • Prostratin induces lytic gene expression, suggesting a role in Kaposi's sarcoma-associated herpesvirus reactivation.

Conclusions:

  • Prostratin is a promising therapeutic agent with a favorable safety profile.
  • Prostratin's unique mechanism involving PKC activation offers novel therapeutic strategies.
  • Further research into prostratin's applications in virology and oncology is warranted.