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A study comparing a gestoden triphasic formulation with a fixed combination OC.

T Agoestina1, U Sabarudin, G Hoppe

  • 1Department of Obstetrics and Gynecology, Hasan Sadikin Hospital, University of Padjadgaran, Bandung, Indonesia.

Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
|June 1, 1989
PubMed
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This study found that modern low-dose oral contraceptives, including those with gestoden, show clinically insignificant metabolic changes. Blood test results remained within normal ranges, maintaining a healthy balance in coagulation and fibrinolysis.

Area of Science:

  • Reproductive endocrinology and metabolism.
  • Pharmacology of hormonal contraceptives.

Background:

  • Modern low-dose oral contraceptives are widely used for family planning.
  • Previous studies suggest minimal metabolic impact from these formulations.
  • Gestoden is a progestogen used in triphasic oral contraceptive pills.

Purpose of the Study:

  • To evaluate the metabolic effects of a triphasic gestoden formulation compared to a desogestrel-containing pill.
  • To assess changes in lipoprotein, coagulation, fibrinolytic, and liver function parameters.
  • To confirm findings from previous metabolic studies on low-dose oral contraceptives.

Main Methods:

  • Double-blind, randomized comparative trial.
  • 30 patients over 12 treatment cycles.

Related Experiment Videos

  • Analysis of metabolic parameters including lipoprotein, coagulation, fibrinolysis, and liver function tests.

    • Main Results:

    • No clinically or statistically significant metabolic changes were observed with either formulation.
    • All laboratory test values remained within normal ranges throughout the study.
    • The balance between coagulation and fibrinolysis was favorably maintained.

    Conclusions:

    • Triphasic gestoden and desogestrel-containing oral contraceptives demonstrate minimal metabolic impact.
    • These hormonal contraceptives maintain normal physiological parameters and a healthy hemostatic balance.
    • Findings support the safety profile of modern low-dose oral contraceptives regarding metabolic function.