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SLE myopathy: a clinicopathological study.

Saumya Jakati1, Liza Rajasekhar2, Megha Uppin1

  • 1Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

International Journal of Rheumatic Diseases
|May 13, 2015
PubMed
Summary
This summary is machine-generated.

Histological examination revealed myositis in nearly half of systemic lupus erythematosus (SLE) patients with muscle symptoms. Type 2 atrophy, not myositis, was the primary cause of muscle issues in these SLE patients.

Keywords:
SLE myositisperivascular inflammationtype 2 atrophy

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Area of Science:

  • Rheumatology
  • Neurology
  • Pathology

Background:

  • Systemic lupus erythematosus (SLE) can present with diverse clinical manifestations, including muscle symptoms.
  • Muscle involvement in SLE requires accurate diagnosis, often necessitating muscle biopsy for histological evaluation.

Purpose of the Study:

  • To investigate the histological changes observed in muscle biopsies of patients diagnosed with systemic lupus erythematosus (SLE) who exhibit muscle symptoms.

Main Methods:

  • A cohort of SLE patients with muscle symptoms undergoing muscle biopsy between 2010 and 2014 was analyzed.
  • Demographic, clinical, serological, and electromyoneurography data were collected.
  • Muscle biopsies were assessed for inflammation, fiber abnormalities, vasculitis, and interstitial changes using established criteria.

Main Results:

  • Histological evidence of myositis was identified in 46.66% of biopsied SLE patients with muscle symptoms, significantly higher than clinical diagnoses.
  • Type 2 atrophy was the predominant finding (13/15 patients), observed irrespective of myositis presence or treatment.
  • No significant differences in clinical or laboratory features were found between SLE patients with or without myositis on biopsy.

Conclusions:

  • Histological myositis is present in a substantial proportion of SLE patients with muscle symptoms.
  • Type 2 atrophy is a frequent finding and likely the primary contributor to muscle symptoms in SLE, regardless of myositis.
  • Muscle biopsy is crucial for diagnosing myositis in SLE, but type 2 atrophy should be considered a major cause of muscle symptoms.