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Published on: September 20, 2024
Nuclear survivin expression in small cell lung cancer
Yukihiro Yano1, Tomoyuki Otsuka2, Hiroshi Hirano3
1Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan yanoy@toneyama.go.jp.
Background/Aim:
Little evidence exists regarding a relationship between survivin expression and prognosis in small cell lung cancer (SCLC). We investigated the relationship between survivin expression, clinical characteristics and prognosis in SCLC patients.
Materials And Methods:
We retrospectively reviewed medical records of study patients and analyzed their tumor sections using nuclear survivin labeling index (LI).
Results:
A significant correlation between nuclear survivin LI and clinical stage was found (p=0.012). In multivariate analysis, a significant association was found between survival and clinical stage (hazard ratio (HR)=2.09; 95 % confidence interval (CI)=1.08-4.31; p=0.027) but not between survival and nuclear survivin LI (HR=0.96; 95 % CI=0.91-1.02; p=0.2).
Conclusion:
We did not find any positive relationship between nuclear survivin expression and survival in SCLC patients. Conversely, we found a positive relationship between clinical stage and nuclear survivin LI, which is considered to be useful in deciding treatment strategies.
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