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Related Experiment Videos

Variable efficacy of calcium carbonate tablets.

S M Kobrin1, S J Goldstein, R F Shangraw

  • 1Albert Einstein Medical Center, Kraftsow Division of Nephrology, Philadelphia, PA 19141.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|December 1, 1989
PubMed
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Calcium carbonate tablets, used as supplements and for phosphate binding in kidney disease, were found ineffective in two cases. Product investigation revealed poor disintegration, dissolution, and clinical efficacy, prompting recommendations for healthcare providers.

Area of Science:

  • Pharmacology
  • Nephrology
  • Drug bioavailability

Background:

  • Calcium carbonate tablets are widely used for calcium supplementation and phosphate binding, particularly in patients with renal failure.
  • Effective phosphate binding is crucial for managing hyperphosphatemia in chronic kidney disease (CKD).

Observation:

  • Two reported cases indicated a specific brand of calcium carbonate tablets was ineffective.
  • This prompted a formal investigation into the product's bioavailability and clinical performance.

Findings:

  • The investigated calcium carbonate product exhibited impaired disintegration and dissolution properties.
  • These formulation issues led to a demonstrable lack of clinical efficacy in patients.

Implications:

Related Experiment Videos

  • Physicians and pharmacists should be aware of potential product-specific efficacy issues with calcium carbonate tablets.
  • Recommendations are proposed to help healthcare professionals avoid prescribing or dispensing ineffective calcium carbonate formulations.
  • Ensuring the quality and bioavailability of oral calcium supplements is critical for patient outcomes in nephrology.