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Updated: Apr 12, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Rationalising prescribing: Evidence, marketing and practice-relevant knowledge.
1Center for Healthy Aging, Section for Health Services Research, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5B, PO Box 2099, DK-1014 Copenhagen, Denmark.
Physicians need practical knowledge beyond drug information for rational prescribing in chronic care. Industry representatives meet this need by providing insights into medication use and devices.
Area of Science:
- General Practice
- Pharmacotherapy
- Chronic Care Management
Background:
- 'Rational pharmacotherapy' initiatives aim to curb 'inappropriate' physician prescribing.
- General practitioners (GPs) manage patients with chronic conditions requiring ongoing medication.
Purpose of the Study:
- To explore how rational prescribing initiatives interact with chronic care management.
- To understand GPs' knowledge needs regarding medication and prescribing.
Main Methods:
- Qualitative study involving observations and interviews.
- 20 general practitioners (GPs) in Denmark participated between 2009 and 2011.
Main Results:
- Informing GPs about drug effects, side effects, and price did not meet their knowledge needs.
- GPs require practice-relevant knowledge extending beyond 'rational pharmacotherapy' information.
- GPs seek knowledge about the material aspects of medications and medical devices.
Conclusions:
- 'Rational' prescribing for GPs encompasses patient medication use, not just drug properties.
- GPs' need for practice-relevant knowledge explains industry sales representatives' access to general practices.
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