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Association between MTHFR 677C/T polymorphism and psoriasis risk: a meta-analysis.
1Department of Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.
This meta-analysis found no significant link between the MTHFR 677C/T gene variant and psoriasis risk. Further research confirms this polymorphism is unlikely to be a risk factor for developing psoriasis.
Area of Science:
- Genetics
- Dermatology
- Molecular Biology
Background:
- The methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is studied for its potential role in various diseases.
- Previous research on the association between MTHFR 677C/T and psoriasis risk has yielded conflicting results.
- A comprehensive evaluation is needed to clarify the relationship between this genetic variant and psoriasis susceptibility.
Purpose of the Study:
- To conduct a meta-analysis to comprehensively evaluate the association between the methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism and the risk of developing psoriasis.
- To synthesize existing evidence from multiple studies to provide a more definitive conclusion on this genetic association.
Main Methods:
- A systematic literature search was performed across major databases including PubMed, Embase, Web of Science, CNKI, and CBM.
- Seven relevant studies comprising 1290 psoriasis cases and 1068 healthy controls were included in the meta-analysis.
- Statistical analysis was conducted using STATA 12.0 to assess genotype distributions and odds ratios.
Main Results:
- The combined analysis revealed no statistically significant difference in MTHFR 677C/T genotype distribution between psoriasis patients and healthy controls across various comparison models.
- Subgroup analyses based on ethnicity (Asian and Caucasian populations) also indicated no significant association.
- The odds ratios (OR) and confidence intervals (CI) did not support a link between the MTHFR 677C/T polymorphism and psoriasis risk.
Conclusions:
- This meta-analysis concludes that the methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is unlikely to be associated with an increased risk of psoriasis.
- The findings suggest that this specific genetic variant may not play a significant role in the pathogenesis of psoriasis.
- Further large-scale, well-designed genetic association studies may be warranted to confirm these results.
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