Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

180
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
180
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

126
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
126
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

150
Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
150
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

92
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
92
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

113
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
113
Epigenetic Regulation01:46

Epigenetic Regulation

34.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The combinations of histone lysine demethylase inhibitors with panobinostat exert enhanced effects against head and neck cancer cells.

Experimental cell research·2026
Same author

Shaping the Bioactive Properties of Kombucha Drinks by Using Raw Materials Alternative to Tea.

Molecules (Basel, Switzerland)·2026
Same author

Updated BJP guidelines for transparent and rigorous natural product research.

British journal of pharmacology·2026
Same author

Carcinogenicity of tris(chloropropyl) phosphate, butyraldehyde, and cumyl hydroperoxide.

The Lancet. Oncology·2026
Same author

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review.

British journal of pharmacology·2026
Same author

Immunotherapy in cancer: novel approaches and future perspectives.

British journal of pharmacology·2025

Related Experiment Video

Updated: Apr 12, 2026

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
10:26

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

8.9K

Epigenetics and pharmacology.

Barbara Stefanska1, David J MacEwan2

  • 1Department of Nutrition Science, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA.

British Journal of Pharmacology
|May 13, 2015
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms fine-tune gene activity beyond simple gene regulation, impacting cell function and diseases like cancer. New drugs target these epigenetic pathways to treat human diseases.

More Related Videos

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.1K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.4K

Related Experiment Videos

Last Updated: Apr 12, 2026

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
10:26

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

8.9K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.1K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.4K

Area of Science:

  • Genetics and Molecular Biology
  • Pharmacology

Background:

  • Gene regulation involves complex epigenetic mechanisms, including DNA methylation and histone modifications, which control gene activity.
  • These mechanisms fine-tune gene expression beyond basic transcriptional control, influencing cellular functions and development.

Discussion:

  • Epigenetic dysregulation is implicated in diseases such as cancer and Alzheimer's disease.
  • Emerging pharmacological strategies aim to modulate epigenetic mechanisms for therapeutic benefit.

Key Insights:

  • Epigenetic regulation plays a crucial role in maintaining normal cellular phenotypes and is vital in disease pathogenesis.
  • Advanced understanding of epigenetic mechanisms is paving the way for novel therapeutic interventions.

Outlook:

  • The field of epigenetics is rapidly expanding, revealing new therapeutic targets for human diseases.
  • Pharmacological approaches must evolve to effectively harness the potential of epigenetic regulation in medicine.