Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.5K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.5K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

3.1K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.1K
Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

1.1K
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[From vestibular migraine to cochlear migraine].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2026
Same author

First Detection of Ultrahigh Energy Emission from Gamma-Ray Binary LS I +61° 303.

Physical review letters·2026
Same author

Evidence of Cosmic-Ray Acceleration up to Sub-PeV Energies in the Supernova Remnant IC 443.

Physical review letters·2026
Same author

Precise Measurement of the Cosmic Ray Helium Spectrum above 0.1 PeV.

Physical review letters·2026
Same author

[Research progress on the diagnosis and treatment of benign paroxysmal positional vertigo].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

All-Sky Search for Individual Primordial Black Hole Bursts with LHAASO.

Physical review letters·2025
Same journal

Capturing omega sign in the clinical assessment of depression by deep learning.

Translational psychiatry·2026
Same journal

Postpartum maternal bonding problems relate to aberrant neural processing of infant emotions: Results of an adapted fMRI emotional GoNoGo task.

Translational psychiatry·2026
Same journal

Ecological assessment of transdiagnostic clinical symptoms in serious mental illness with daily smartphone surveys.

Translational psychiatry·2026
Same journal

Microbiota-gut-brain axis in autism spectrum disorder: integrating brain structure, function, and transcriptomics.

Translational psychiatry·2026
Same journal

Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.

Translational psychiatry·2026
Same journal

Maraviroc attenuates inflammation-exacerbated cognitive and amyloid pathology in an early-stage Alzheimer's disease mouse model.

Translational psychiatry·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.9K

A molecular model for neurodevelopmental disorders.

C O Gigek1, E S Chen1, V K Ota1

  • 1Department of Psychiatry, McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada.

Translational Psychiatry
|May 13, 2015
PubMed
Summary
This summary is machine-generated.

Reduced dosage of MBD5 and SATB2 genes disrupts neural stem cell balance, impacting neurodevelopmental disorders (NDDs). This suggests a common pathway in NDDs involving disrupted NSC proliferation and differentiation regulation.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.9K

Related Experiment Videos

Last Updated: Apr 12, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.9K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.7K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.9K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Neurodevelopmental disorders (NDDs) are linked to genes affecting cognition and behavior.
  • Convergent functions and pathways like protein translation, chromatin modification, and synapse assembly are implicated in NDDs.
  • Genes MBD5 and SATB2 are associated with 2q23.1 and 2q33.1 deletion syndromes, respectively.

Purpose of the Study:

  • To develop a generalized model for NDDs by testing the convergent effects of reduced MBD5 and SATB2 dosage in human neural stem cells (NSCs).
  • To investigate the hypothesis that disrupted balance in NSC proliferation and differentiation is a primary etiology of NDDs.

Main Methods:

  • Stable short hairpin RNA-mediated suppression of MBD5 and SATB2 expression in human NSCs.
  • Massively parallel RNA sequencing, DNA methylation sequencing, and microRNA arrays to analyze molecular changes.
  • Comparison of gene expression, microRNA patterns, and DNA methylation states between suppressed and control NSCs.

Main Results:

  • Reduced dosage of either MBD5 or SATB2 led to significant overlap in gene-expression patterns, microRNA profiles, and DNA methylation states with control NSCs in a differentiating state.
  • These findings suggest a shared mechanism in 2q23.1 and 2q33.1 deletion syndromes characterized by dysregulated NSC proliferation and differentiation.
  • Similar effects were previously observed for TCF4 and EHMT1 suppression.

Conclusions:

  • A unifying feature of certain NDDs may be the dysregulation of the balance between NSC proliferation and differentiation.
  • A proposed model suggests that while this balance is crucial for NDDs, the specific molecular drivers vary with genetic variations.
  • The precise regulation of NSC differentiation timing and location is a significant factor underlying the diverse NDD phenotypes.