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Related Experiment Video

Updated: Apr 12, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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Applying developmental programming to clinical obstetrics: my ward round.

R C Painter1

  • 1Department of Obstetrics and Gynaecology,Academic Medical Centre,University of Amsterdam,Amsterdam,The Netherlands.

Journal of Developmental Origins of Health and Disease
|May 14, 2015
PubMed
Summary
This summary is machine-generated.

Developmental programming principles can guide clinical decisions for pregnant women, improving long-term offspring health. This approach influences obstetric and fertility research agendas, highlighting the need for further clinical practice guidance.

Keywords:
humanoffspringpregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Developmental Biology
  • Perinatal Medicine

Background:

  • Accumulating evidence supports the theory of developmental programming, which posits that early life conditions influence long-term health.
  • Clinical application of developmental programming principles in pregnancy care is underexplored.
  • This study examines how developmental programming can inform clinical decision-making and research in obstetrics.

Observation:

  • Clinical scenarios were reviewed at an obstetric referral center to identify applications of developmental programming.
  • Potential applications include preventive measures for preeclampsia, management of maternal obesity and diabetes, and corticosteroid use in cesarean deliveries.
  • Nutritional therapy for hyperemesis gravidarum and reproductive choices like IVF versus expectant management were also considered.

Findings:

  • The offspring's long-term health perspective can guide decisions on calcium and aspirin for preeclampsia prevention.
  • Maternal health conditions during pregnancy, such as obesity and diabetes, require management considering offspring's future health.
  • Further research is needed on the long-term effects of interventions like corticosteroids and nutritional therapy on offspring health.

Implications:

  • Applying developmental programming principles can enhance clinical decision-making in pregnancy care.
  • These concepts are increasingly integrated into clinical practice and shape research outcomes in obstetrics and fertility.
  • More research is crucial to provide robust guidance for integrating developmental programming into routine clinical practice.